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Autophagy and pulmonary disease.


ABSTRACT: Autophagy is a process of cell self-renewal that is dependent on the degradation of the cytoplasmic proteins or organelles of lysosomes. Many diseases, such as metabolic diseases, cancer, neurodegenerative diseases, and lung diseases, have been confirmed to be associated with elevated or impaired levels of autophagy. At present, studies have found that autophagy participates in the regulation of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, acute lung injury, lung cancer, and other pulmonary diseases. Using recent literature on the signal transduction mechanisms of autophagy and the effects of autophagy signalling on lung diseases, this review intends to clarify the mechanisms of lung disease to guide the treatment of related diseases. The reviews of this paper are available via the supplemental material section.

SUBMITTER: Liao SX 

PROVIDER: S-EPMC6887802 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature

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Autophagy and pulmonary disease.

Liao Shi-Xia SX   Sun Peng-Peng PP   Gu Yan-Hui YH   Rao Xi-Min XM   Zhang Lan-Ying LY   Ou-Yang Yao Y  

Therapeutic advances in respiratory disease 20190101


Autophagy is a process of cell self-renewal that is dependent on the degradation of the cytoplasmic proteins or organelles of lysosomes. Many diseases, such as metabolic diseases, cancer, neurodegenerative diseases, and lung diseases, have been confirmed to be associated with elevated or impaired levels of autophagy. At present, studies have found that autophagy participates in the regulation of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension,  ...[more]

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