Ontology highlight
ABSTRACT:
SUBMITTER: Haspel JA
PROVIDER: S-EPMC3262043 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Haspel Jeffrey A JA Choi Augustine M K AM
American journal of respiratory and critical care medicine 20110811 11
Autophagy is a highly conserved homeostatic pathway by which cells transport damaged proteins and organelles to lysosomes for degradation. Dysregulation of autophagy contributes to the pathogenesis of clinically important disorders in a variety of organ systems but, until recently, little was known about its relationship to diseases of the lung. However, there is now growing evidence at the basic research level that autophagy is linked to the pathogenesis of important pulmonary disorders such as ...[more]