Ontology highlight
ABSTRACT:
SUBMITTER: Schille JT
PROVIDER: S-EPMC6888667 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Schille Jan Torben JT Nolte Ingo I Packeiser Eva-Maria EM Wiesner Laura L Hein Jens Ingo JI Weiner Franziska F Wu Xiao-Feng XF Beller Matthias M Junghanss Christian C Murua Escobar Hugo H
International journal of molecular sciences 20191107 22
Current therapies are insufficient for metastatic prostate cancer (PCa) in men and dogs. As human castrate-resistant PCa shares several characteristics with the canine disease, comparative evaluation of novel therapeutic agents is of considerable value for both species. Novel isoquinolinamine FX-9 exhibits antiproliferative activity in acute lymphoblastic leukemia cell lines but has not been tested yet on any solid neoplasia type. In this study, FX-9's mediated effects were characterized on two ...[more]