Ontology highlight
ABSTRACT:
SUBMITTER: Catuogno S
PROVIDER: S-EPMC6889555 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Catuogno Silvia S Di Martino Maria Teresa MT Nuzzo Silvia S Esposito Carla Lucia CL Tassone Pierfrancesco P de Franciscis Vittorio V
Molecular therapy. Nucleic acids 20191028
B cell maturation antigen is highly expressed on malignant plasma cells in human multiple myeloma and has recently emerged as a very promising target for therapeutic interventions. Nucleic-acid-based aptamers are small oligonucleotides with high selective targeting properties and functional advantages over monoclonal antibodies, as both diagnostic and therapeutic tools. Here, we describe the generation of the first-ever-described nuclease resistant RNA aptamer selectively binding to B cell matur ...[more]