Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic therapy† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc03161h.

ABSTRACT: The inherent hypoxic environment in tumors severely resists the efficacy of photodynamic therapy. To address this problem, herein, the strategy of using oxygen self-sufficient liposomes (denoted as CaO2/B1/NH4HCO3 lipo), which contained aza-BODIPY dye (B1) and CaO2 nanoparticles in the hydrophobic layer and NH4HCO3 in the hydrophilic cavity, was presented to overcome hypoxia-associated photodynamic resistance. Under near-infrared (NIR) irradiation, NIR-absorbable B1 was activated to induce hyperthermia and further triggered the decomposition of NH4HCO3. Subsequently, with the aid of NH4HCO3 and CaO2 nanoparticles, oxygen was rapidly and self-sufficiently generated, during which clean by-products were produced. Furthermore, the increased amount of oxygen promoted the singlet oxygen production in the presence of B1, which served as a photosensitizer because of the heavy atom effect. The oxygen self-sufficient system improved the anticancer efficiency and alleviated the hypoxic environment in vivo, which demonstrated a valuable attempt to regulate intratumoral hypoxia and overcome the limitation of current photodynamic therapy systems. To our knowledge, this highlights the first example of using NIR light to activate CaO2 nanoparticle-containing liposomes for the modulation of the hypoxic environment in tumors.

SUBMITTER: Yu Q

PROVIDER: S-EPMC6889832 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

On donor–acceptor-bridging intramolecular hydrogen bonds in NIR-TADF molecules† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2ra07450h

Project description:Following a report that highlights the importance of intramolecular hydrogen bonds for improved NIR-TADF efficiency in CAT-1 [Leng et al., J. Phys Chem. A, 2021, 125, 2905], an intramolecularly doubly hydrogen-bonded base design is investigated and compared to singly and non-bonded derivatives. It is found that the potential to form more intramolecular hydrogen bonds correlates with decreasing internal reorganization energies in most of the designed structures. In addition, our proposed base design facilitates the desired interlocking of charge transfer donor-, linker- and acceptor-planes through steric gauche-interactions to both linker-plane sides, allowing to trap also smaller heterocyclic linkers. Following a report that highlights the importance of intramolecular hydrogen bonds for improved NIR-TADF efficiency, an intramolecularly doubly hydrogen-bonded base design is investigated and compared to singly and non-bonded derivatives.

| S-EPMC9891092 | biostudies-literature

Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2sc05242c

Project description:Clear elucidation of the changes in Alzheimer's disease (AD)-related methylglyoxal (MGO) levels in vivo is significant yet highly challenging. Fluorescence imaging in the second near-infrared region (NIR-II, 1000–1700 nm) has gained increasing attention as an observation method in living organisms, but an MGO-activatable fluorescent probe that emits in this region for in vivo brain imaging is lacking because of the existence of the blood–brain barrier (BBB). Herein, a biocompatible Fe3O4 nanoparticle (IONP)-conjugated MGO-activatable NIR-II fluorescent probe (MAM) modified with the peptide T7 (HAIYPRH) (named TM-IONP) is reported for the in situ detection of MGO in a transgenic AD mouse model. In this system, the T7 peptide enhances BBB crossing and brain accumulation by specifically targeting transferrin receptors on the BBB. Due to the MAM probe, TM-IONPs emit fluorescence in the NIR-II region and display high selectivity with an MGO detection limit of 72 nM and a 10-fold increase in the fluorescence signal. After intravenous administration, the TM-IONPs are easily delivered to the brain and pass through the BBB without intervention, and as a result, the brains of AD mice can be noninvasively imaged for the first time by the in situ detection of MGO with a 24.2-fold enhancement in NIR-II fluorescence intensity compared with wild-type mice. Thus, this MGO-activated NIR-II-emitting nanoprobe is potentially useful for early AD diagnosis in clinic. A biocompatible Fe3O4 nanoparticle integrating methylglyoxal-activatable NIR-II fluorescent probe and brain-targeting peptide was developed for visualizing Alzheimer's disease (AD)-related methylglyoxal variation in vivo.

| S-EPMC9628982 | biostudies-literature

Img2Mol – accurate SMILES recognition from molecular graphical depictions† † Electronic supplementary information (ESI) available. See DOI: 10.1039/d1sc01839f

Project description:The automatic recognition of the molecular content of a molecule's graphical depiction is an extremely challenging problem that remains largely unsolved despite decades of research. Recent advances in neural machine translation enable the auto-encoding of molecular structures in a continuous vector space of fixed size (latent representation) with low reconstruction errors. In this paper, we present a fast and accurate model combining deep convolutional neural network learning from molecule depictions and a pre-trained decoder that translates the latent representation into the SMILES representation of the molecules. This combination allows us to precisely infer a molecular structure from an image. Our rigorous evaluation shows that Img2Mol is able to correctly translate up to 88% of the molecular depictions into their SMILES representation. A pretrained version of Img2Mol is made publicly available on GitHub for non-commercial users. The automatic recognition of the molecular content of a molecule's graphical depiction is an extremely challenging problem that remains largely unsolved despite decades of research.

| S-EPMC8565361 | biostudies-literature

Carbon/ZrO2 aerogel composite microtube superfoam† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4ra00109e

Project description: Not available

| S-EPMC10906140 | biostudies-literature

Antiferromagnetic skyrmion-based high speed diode† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2na00748g

Project description:Antiferromagnetic (AFM) skyrmions are favored over ferromagnetic (FM) skyrmions as they can be driven parallel to in-plane driving currents and eventually prevent the annihilation at the edges of nanotrack. In this study, an AFM skyrmion-based diode is proposed to realize the one-way skyrmion motion that is crucial for data processing in nanoelectronic and spintronic devices. The skyrmion transport is controlled by exploiting the staircase notch region in the middle of the nanotrack. By virtue of this, the micromagnetic interaction energy between the skyrmion and the notch edges generates a potential gradient that further gives rise to repulsive forces on the skyrmion. The resultant of the forces from the driving current and edge repulsions make the skyrmion move along the notch region to overcome the device window and reach the detection region. The notch is designed in such a way that it prevents the movement of the skyrmion in the reverse direction, thereby achieving diode functionality. The proposed device offers processing speed in the order of 103 m s−1, hence paving the way for the development of energy-efficient and high-speed devices in antiferromagnetic spintronics. An AFM skyrmion based diode is designed using a staircase notch region at the middle of the nanotrack. The notch region induces the change in potential energy and acts as a barrier, thus allowing the unidirectional motion of the skyrmion.

| S-EPMC9846466 | biostudies-literature

Nα-arylsulfonyl histamines as selective β-glucosidase inhibitors† † Electronic supplementary information (ESI) available. See DOI: 10.1039/c8ra06625f

Project description:Nα-benzenesulfonylhistamine, a new semi-synthetic β-glucosidase inhibitor, was obtained by bioactivity-guided isolation from a chemically engineered extract of Urtica urens L. prepared by reaction with benzenesulfonyl chloride. In order to identify better β-glucosidase inhibitors, a new series of Nα,Nτ-di-arylsulfonyl and Nα-arylsulfonyl histamine derivatives was prepared. Biological studies revealed that the β-glucosidase inhibition was in a micromolar range for several Nα-arylsulfonyl histamine compounds of the series, Nα-4-fluorobenzenesulfonyl histamine being the most powerful compound. Besides, this reversible and competitive inhibitor presented a good selectivity for β-glucosidase with respect to other target enzymes including α-glucosidase. A selective β-glucosidase inhibitor was discovered using the chemically engineered extracts approach.

| S-EPMC9088825 | biostudies-literature

New fluorene-based bipolar charge transporting materials† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ra07583d

Project description: Not available

| S-EPMC10794882 | biostudies-literature

Mechanochemically assisted morphing of shape shifting polymers† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3sc02404k

Project description:Morphing in creatures has inspired various synthetic polymer materials that are capable of shape shifting. The morphing of polymers generally relies on stimuli-active (typically heat and light active) units that fix the shape after a mechanical load-based shape programming. Herein, we report a strategy that uses a mechanochemically active 2,2′-bis(2-phenylindan-1,3-dione) (BPID) mechanophore as a switching unit for mechanochemical morphing. The mechanical load on the polymer triggers the dissociation of the BPID moiety into stable 2-phenylindan-1,3-dione (PID) radicals, whose subsequent spontaneous dimerization regenerates BPID and fixes the temporary shapes that can be effectively recovered to the permanent shapes by heating. A greater extent of BPID activation, through a higher BPID content or mechanical load, leads to higher mechanochemical shape fixity. By contrast, a relatively mechanochemically less active hexaarylbiimidazole (HABI) mechanophore shows a lower fixing efficiency when subjected to the same programing conditions. Another control system without a mechanophore shows a low fixing efficiency comparable to the HABI system. Additionally, the introduction of the BPID moiety also manifests remarkable mechanochromic behavior during the shape programing process, offering a visualizable indicator for the pre-evaluation of morphing efficiency. Unlike conventional mechanical mechanisms that simultaneously induce morphing, such as strain-induced plastic deformation or crystallization, our mechanochemical method allows for shape programming after the mechanical treatment. Our concept has potential for the design of mechanochemically programmable and mechanoresponsive shape shifting polymers. A 2,2′-bis(2-phenylindan-1,3-dione) (BPID) mechanophore is applied as a switching unit for mechanochemical morphing of polymers. Mechancial force activates the BPID into stable PID radicals, whose subsequent dimerization fixes the temporary shapes.

| S-EPMC10466301 | biostudies-literature

Engineering the interface in mechanically responsive graphene-based films† † Electronic supplementary information (ESI) available. See DOI: 10.1039/c8ra07974a

Project description:Due to their extraordinary mechanical properties, nanocarbon materials (e.g. carbon nanotube and graphene) are attracting great interests in the field of nanocomposites. One unique feature in nanocarbon-based nanocomposites is their intrinsically rich interface, allowing them to adapt the microstructures in response to external loading and, in turn, to stiffen themselves. This mechanical behavior, called responsive stiffening, was usually observed in biological materials such as bones and muscles. The mechanically responsive behaviors of nanocarbon-based materials are particularly exciting because the nanocarbon-enabled huge interface area offers opportunities to tune such stiffening performance while this interface advantage is not fully exploited yet. Here, we demonstrate stiffening behaviors in graphene oxide (GO)-based film materials in response to dynamic oscillations. Through a facile method of polymer content alteration and alkali treatment, the microstructure and interlayer interaction of GO films are modified, along with the resulted responsively stiffening performance. Based on polarized Raman spectra characterizations, we attribute the stiffening mechanism to the microstructural evolution of GO films during dynamic tension as well as the polymer chains alignment. Finally, we highlight the significantly improved static mechanical properties of GO film after a simple stiffening process. Our results not only aid in the development of biomimetic, adaptive materials, but provide a mechanical way for the design of high-performance nanocarbon-based nanocomposites. Engineering interface and microstructures to improve mechanical performance of graphene-based films via a “mechanical” way.

| S-EPMC9088400 | biostudies-literature

Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.

Project description:G9a is a histone lysine methyltransferase (HKMT) involved in epigenetic regulation via the installation of histone methylation marks. 6,7-Dimethoxyquinazoline analogues, such as BIX-01294, are established as potent, substrate competitive inhibitors of G9a. With an objective to identify novel chemotypes for substrate competitive inhibitors of G9a, we have designed and synthesised a range of heterocyclic scaffolds, and investigated their ability to inhibit G9a. These studies have led to improved understanding of the key pharmacophoric features of BIX-01294 and the identification of a new core quinoline inhibitory scaffold, which retains excellent potency and high selectivity. Molecular docking was carried out to explain the observed in vitro data.

| S-EPMC4349132 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data