Ontology highlight
ABSTRACT:
SUBMITTER: Chakraborty S
PROVIDER: S-EPMC6890761 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Chakraborty Saptarshi S Arora Arshi A Begg Colin B CB Shen Ronglai R
Nature communications 20191203 1
To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon statistical methodology that has been developed in other fields of study, notably in species estimation in ecology, and word frequency estimation in computational linguistics. Analysis o ...[more]