Ontology highlight
ABSTRACT:
SUBMITTER: Bondaz A
PROVIDER: S-EPMC6891102 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Bondaz Alexandra A Cirillo Luca L Meraldi Patrick P Gotta Monica M
The Journal of cell biology 20191023 12
In animal cells, faithful chromosome segregation depends on the assembly of a bipolar spindle driven by the timely separation of the two centrosomes. Here we took advantage of the highly stereotypical cell divisions in <i>Caenorhabditis elegans</i> embryos to identify new regulators of centrosome separation. We find that at the two-cell stage, the somatic AB cell initiates centrosome separation later than the germline P1 cell. This difference is strongly exacerbated by the depletion of the kines ...[more]