Ontology highlight
ABSTRACT:
SUBMITTER: Dongol Y
PROVIDER: S-EPMC6891507 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Toxins 20191029 11
Voltage-gated sodium channels (Na<sub>V</sub>s) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit Na<sub>V</sub> channels have helped unravel the role of Na<sub>V</sub> channels in diseases, including chronic pain. Spider venoms contain the most diverse array of inhibitor cystine knot (ICK) toxins (knottins). This review provides an overview on how spider knottins modulate Na<sub>V</sub> channels and describes the structural features ...[more]