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Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis.


ABSTRACT:

Objective

To determine associations between important pre-arrest and intra-arrest prognostic factors and survival after in-hospital cardiac arrest.

Design

Systematic review and meta-analysis.

Data sources

Medline, PubMed, Embase, Scopus, Web of Science, and the Cochrane Database of Systematic Reviews from inception to 4 February 2019. Primary, unpublished data from the United Kingdom National Cardiac Arrest Audit database.

Study selection criteria

English language studies that investigated pre-arrest and intra-arrest prognostic factors and survival after in-hospital cardiac arrest.

Data extraction

PROGRESS (prognosis research strategy group) recommendations and the CHARMS (critical appraisal and data extraction for systematic reviews of prediction modelling studies) checklist were followed. Risk of bias was assessed by using the QUIPS tool (quality in prognosis studies). The primary analysis pooled associations only if they were adjusted for relevant confounders. The GRADE approach (grading of recommendations assessment, development, and evaluation) was used to rate certainty in the evidence.

Results

The primary analysis included 23 cohort studies. Of the pre-arrest factors, male sex (odds ratio 0.84, 95% confidence interval 0.73 to 0.95, moderate certainty), age 60 or older (0.50, 0.40 to 0.62, low certainty), active malignancy (0.57, 0.45 to 0.71, high certainty), and history of chronic kidney disease (0.56, 0.40 to 0.78, high certainty) were associated with reduced odds of survival after in-hospital cardiac arrest. Of the intra-arrest factors, witnessed arrest (2.71, 2.17 to 3.38, high certainty), monitored arrest (2.23, 1.41 to 3.52, high certainty), arrest during daytime hours (1.41, 1.20 to 1.66, high certainty), and initial shockable rhythm (5.28, 3.78 to 7.39, high certainty) were associated with increased odds of survival. Intubation during arrest (0.54, 0.42 to 0.70, moderate certainty) and duration of resuscitation of at least 15 minutes (0.12, 0.07 to 0.19, high certainty) were associated with reduced odds of survival.

Conclusion

Moderate to high certainty evidence was found for associations of pre-arrest and intra-arrest prognostic factors with survival after in-hospital cardiac arrest.

Systematic review registration

PROSPERO CRD42018104795.

SUBMITTER: Fernando SM 

PROVIDER: S-EPMC6891802 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis.

Fernando Shannon M SM   Tran Alexandre A   Cheng Wei W   Rochwerg Bram B   Taljaard Monica M   Vaillancourt Christian C   Rowan Kathryn M KM   Harrison David A DA   Nolan Jerry P JP   Kyeremanteng Kwadwo K   McIsaac Daniel I DI   Guyatt Gordon H GH   Perry Jeffrey J JJ  

BMJ (Clinical research ed.) 20191204


<h4>Objective</h4>To determine associations between important pre-arrest and intra-arrest prognostic factors and survival after in-hospital cardiac arrest.<h4>Design</h4>Systematic review and meta-analysis.<h4>Data sources</h4>Medline, PubMed, Embase, Scopus, Web of Science, and the Cochrane Database of Systematic Reviews from inception to 4 February 2019. Primary, unpublished data from the United Kingdom National Cardiac Arrest Audit database.<h4>Study selection criteria</h4>English language st  ...[more]

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