Ontology highlight
ABSTRACT:
SUBMITTER: Tang K
PROVIDER: S-EPMC6891986 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Tang Kujin K Ren Jie J Sun Fengzhu F
Genome biology 20191204 1
Alignment-free methods, more time and memory efficient than alignment-based methods, have been widely used for comparing genome sequences or raw sequencing samples without assembly. However, in this study, we show that alignment-free dissimilarity calculated based on sequencing samples can be overestimated compared with the dissimilarity calculated based on their genomes, and this bias can significantly decrease the performance of the alignment-free analysis. Here, we introduce a new alignment-f ...[more]