Ontology highlight
ABSTRACT:
SUBMITTER: Angrisano F
PROVIDER: S-EPMC6892906 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Angrisano Fiona F Sala Katarzyna A KA Tapanelli Sofia S Christophides George K GK Blagborough Andrew M AM
Scientific reports 20191204 1
Inhibiting transmission of Plasmodium is an essential strategy in malaria eradication, and the biological process of gamete fusion during fertilization is a proven target for this approach. Lack of knowledge of the mechanisms underlying fertilization have been a hindrance in the development of transmission-blocking interventions. Here we describe a protein disulphide isomerase essential for malarial transmission (PDI-Trans/PBANKA_0820300) to the mosquito. We show that PDI-Trans activity is male- ...[more]