Ontology highlight
ABSTRACT:
SUBMITTER: Viswanathan R
PROVIDER: S-EPMC6893285 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Viswanathan Ranjith R Necakov Aleksandar A Trylinski Mateusz M Harish Rohit Krishnan RK Krueger Daniel D Esposito Emilia E Schweisguth Francois F Neveu Pierre P De Renzis Stefano S
EMBO reports 20191031 12
Spatio-temporal regulation of signalling pathways plays a key role in generating diverse responses during the development of multicellular organisms. The role of signal dynamics in transferring signalling information in vivo is incompletely understood. Here, we employ genome engineering in Drosophila melanogaster to generate a functional optogenetic allele of the Notch ligand Delta (opto-Delta), which replaces both copies of the endogenous wild-type locus. Using clonal analysis, we show that opt ...[more]