Ontology highlight
ABSTRACT:
SUBMITTER: Brandstadter JD
PROVIDER: S-EPMC6893402 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Brandstadter Joshua D JD Maillard Ivan I
Open biology 20191106 11
The evolutionarily conserved Notch signalling pathway regulates the differentiation and function of mature T lymphocytes with major context-dependent consequences in host defence, autoimmunity and alloimmunity. The emerging effects of Notch signalling in T cell responses build upon a more established role for Notch in T cell development. Here, we provide a critical review of this burgeoning literature to make sense of what has been learned so far and highlight the experimental strategies that ha ...[more]