Ontology highlight
ABSTRACT:
SUBMITTER: Nascimento JM
PROVIDER: S-EPMC6893972 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Nascimento Juliana Minardi JM Saia-Cereda Verônica M VM Sartore Rafaela C RC da Costa Rodrigo Madeiro RM Schitine Clarissa S CS Freitas Hercules Rezende HR Murgu Michael M de Melo Reis Ricardo A RA Rehen Stevens K SK Martins-de-Souza Daniel D
Frontiers in cell and developmental biology 20191128
The limited access to functional human brain tissue has led to the development of stem cell-based alternative models. The differentiation of human pluripotent stem cells into cerebral organoids with self-organized architecture has created novel opportunities to study the early stages of the human cerebral formation. Here we applied state-of-the-art label-free shotgun proteomics to compare the proteome of stem cell-derived cerebral organoids to the human fetal brain. We identified 3,073 proteins ...[more]