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Developing degraders: principles and perspectives on design and chemical space.

ABSTRACT: Degraders (e.g. PROTACs, SNIPERs, degronimers etc.) are a new modality offering increasing potential both as tools for basic research and therapeutic development. They occupy chemical space that lies outside the classical Lipinski 'Rule of 5', which poses fresh challenges for achieving cell permeability and oral bioavailability. This study presents a comprehensive database of degrader structures from the peer reviewed literature, including both optimized degraders and first generation compounds, in order to provide a thorough assessment of the chemical space associated with this modality and identify common trends used during the 'hit to lead' process. The results provide insights into this new area of chemical space as well as pointers for degrader design, which we anticipate will be useful for researchers entering this field.

SUBMITTER: Maple HJ

PROVIDER: S-EPMC6894040 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Developing degraders: principles and perspectives on design and chemical space.

Maple Hannah J HJ Clayden Nat N Baron Anne A Stacey Callum C Felix Robert R

MedChemComm 20190812 10

Degraders (<i>e.g.</i> PROTACs, SNIPERs, degronimers <i>etc.</i>) are a new modality offering increasing potential both as tools for basic research and therapeutic development. They occupy chemical space that lies outside the classical Lipinski 'Rule of 5', which poses fresh challenges for achieving cell permeability and oral bioavailability. This study presents a comprehensive database of degrader structures from the peer reviewed literature, including both optimized degraders and first generat ...[more]

PMID: 31867093

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