Ontology highlight
ABSTRACT:
SUBMITTER: Hughes SJ
PROVIDER: S-EPMC5869862 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Hughes Scott J SJ Ciulli Alessio A
Essays in biochemistry 20171108 5
Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought 'undruggable' targets at sub-stoichiometric concentrations in ways not possible using conventional inhibitors. Mounting evidence suggests these chemical agents, in concert with their target proteins, can be modelled as three-body binding equilibria that can exhibit significant cooperativity as a result of ...[more]