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Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway.

ABSTRACT: Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death receptor-1 (PD-1) and its ligand (PD-L1) demonstrate impressive clinical benefits in clinical trials. In this review, we present background information about therapies involving PD-1/PD-L1 blockade and provide an overview of current clinical trials. Furthermore, we present recent advances involving predictive biomarkers associated with positive therapeutic outcomes in cancer immunotherapy.

SUBMITTER: Wakabayashi G

PROVIDER: S-EPMC6894306 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway.

Wakabayashi Grace G Lee Yu-Ching YC Luh Frank F Kuo Chun-Nan CN Chang Wei-Chiao WC Yen Yun Y

Journal of biomedical science 20191205 1

Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death receptor-1 (PD-1) and its ligand (PD-L1) demonstrate impressive clinical benefits in clinical trials. In this review, we present background information about therapies involving PD-1/PD-L1 blockade and provide an overview of current cl ...[more]

PMID: 31801525

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