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Contribution of platelets to tumour metastasis.

ABSTRACT: Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.

SUBMITTER: Gay LJ

PROVIDER: S-EPMC6894505 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Contribution of platelets to tumour metastasis.

Gay Laurie J LJ Felding-Habermann Brunhilde B

Nature reviews. Cancer 20110201 2

Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy. ...[more]

PMID: 21258396

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Correction To: Tumour-educated platelets for breast cancer detection: biological and technical insights.

Project description: Not available

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