Ontology highlight
ABSTRACT:
SUBMITTER: Hoerrner ME
PROVIDER: S-EPMC6894616 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Organic letters 20190829 18
A Suzuki-Miyaura cross-coupling of α-pyridinium esters and arylboroxines has been developed. Combined with formation of the pyridinium salts from amino acid derivatives, this method enables amino acid derivatives to be efficiently transformed into α-aryl esters and amides. Under the mild conditions, broad functional group tolerance on both the amino acid derivatives and the arylboroxine are observed, including protic functional groups. Mechanistic studies support an alkyl radical intermediate, s ...[more]