Vinculins interaction with talin is essential for mammary epithelial differentiation.
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ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC6895056 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Vinculins interaction with talin is essential for mammary epithelial differentiation.
Wang Pengbo P Wu Jian J Wood Amber A Jones Matthew M Pedley Robert R Li Weiping W Ross Robert S RS Ballestrem Christoph C Gilmore Andrew P AP Streuli Charles H CH
Scientific reports 20191205 1
Vinculin is an essential component of cell adhesion complexes, where it regulates the strength and stability of adhesions. Whilst the role of vinculin in cell motility is well established, it remains unclear how vinculin contributes to other aspects of tissue function. Here we examine the role of vinculin in mammary epithelial cell phenotype. In these cells, correct adhesion to the extracellular matrix is essential for both the formation of polarised secretory acini and for the transcription of ...[more]
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