Ontology highlight
ABSTRACT:
SUBMITTER: Cerniauskas I
PROVIDER: S-EPMC6895430 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Cerniauskas Ignas I Winterer Jochen J de Jong Johannes W JW Lukacsovich David D Yang Hongbin H Khan Fawwad F Peck James R JR Obayashi Sophie K SK Lilascharoen Varoth V Lim Byung Kook BK Földy Csaba C Lammel Stephan S
Neuron 20191028 5
Chronic stress (CS) is a major risk factor for the development of depression. Here, we demonstrate that CS-induced hyperactivity in ventral tegmental area (VTA)-projecting lateral habenula (LHb) neurons is associated with increased passive coping (PC), but not anxiety or anhedonia. LHb→VTA neurons in mice with increased PC show increased burst and tonic firing as well as synaptic adaptations in excitatory inputs from the entopeduncular nucleus (EP). In vivo manipulations of EP→LHb or LHb→VTA neu ...[more]