Ontology highlight
ABSTRACT:
SUBMITTER: Castillejo A
PROVIDER: S-EPMC6896897 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Castillejo Adela A Rothman Nathaniel N Murta-Nascimento Cristiane C Malats Núria N García-Closas Montserrat M Gómez-Martínez Angeles A Lloreta Josep J Tardón Adonina A Serra Consol C García-Closas Reina R Chanock Stephen S Silverman Debra T DT Dosemeci Mustafa M Kogevinas Manolis M Carrato Alfredo A Soto José Luis JL Real Francisco X FX
International journal of cancer 20090201 3
The transforming growth factor-beta (TGF-beta) signalling pathway plays an important role in tumor development and progression. We aimed at analyzing whether 7 different common variants in genes coding for 2 key members of the TGF-beta signalling pathway (TGFB1 and TGFBR1) are associated with bladder cancer risk and prognosis. A total of 1,157 cases with urothelial cell carcinoma of the bladder and 1,157 matched controls where genotyped for 3 single nucleotide polymorphisms (SNPs) in TGFB1 (rs19 ...[more]