Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC6898380 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Zhang Shilu S Chasman Deborah D Knaack Sara S Roy Sushmita S
Nature communications 20191206 1
The three-dimensional (3D) organization of the genome plays an important role in gene regulation bringing distal sequence elements in 3D proximity to genes hundreds of kilobases away. Hi-C is a powerful genome-wide technique to study 3D genome organization. Owing to experimental costs, high resolution Hi-C datasets are limited to a few cell lines. Computational prediction of Hi-C counts can offer a scalable and inexpensive approach to examine 3D genome organization across multiple cellular conte ...[more]