Ontology highlight
ABSTRACT:
SUBMITTER: Cameron CJ
PROVIDER: S-EPMC6961295 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cameron Christopher Jf CJ Dostie Josée J Blanchette Mathieu M
Genome biology 20200114 1
Hi-C is a popular technique to map three-dimensional chromosome conformation. In principle, Hi-C's resolution is only limited by the size of restriction fragments. However, insufficient sequencing depth forces researchers to artificially reduce the resolution of Hi-C matrices at a loss of biological interpretability. We present the Hi-C Interaction Frequency Inference (HIFI) algorithms that accurately estimate restriction-fragment resolution Hi-C matrices by exploiting dependencies between neigh ...[more]