Dataset Information
Checkpoint inhibitor failure in hypermutated and mismatch repair-mutated recurrent high-grade gliomas.
Ontology highlight
ABSTRACT: Background
Recurrent high-grade gliomas in adults remain a deadly cancer with median survival of less than 1 year. In the absence of effective agents, immunotherapy with checkpoint inhibitors has been adopted as a potentially beneficial next step for recurrences with hypermutated or mismatch repair-mutated phenotypes. The rationale for their use, however, is based on case reports and studies with other types of cancer.Methods
We reviewed 4 cases of hypermutated or mismatch repair-mutated recurrent high-grade gliomas treated with checkpoint inhibitors.Results
All cases had recurrent high-grade glioma that harbored either a hypermutated phenotype and/or a mismatch repair mutation. Treatment with checkpoint inhibitor therapy resulted in no significant response.Conclusions
In our experience, hypermutated or mismatch repair-mutated high-grade gliomas in adults do not respond to checkpoint inhibitors alone. This lack of efficacy is in agreement with underwhelming results of clinical trials examining checkpoint inhibitors in high-grade gliomas. The case reports of responders have been in pediatric patients with glioma and are likely a different subtype altogether.
SUBMITTER: Ahmad H
PROVIDER: S-EPMC6899050 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Checkpoint inhibitor failure in hypermutated and mismatch repair-mutated recurrent high-grade gliomas.
Neuro-oncology practice 20190407 6
<h4>Background</h4>Recurrent high-grade gliomas in adults remain a deadly cancer with median survival of less than 1 year. In the absence of effective agents, immunotherapy with checkpoint inhibitors has been adopted as a potentially beneficial next step for recurrences with hypermutated or mismatch repair-mutated phenotypes. The rationale for their use, however, is based on case reports and studies with other types of cancer.<h4>Methods</h4>We reviewed 4 cases of hypermutated or mismatch repair ...[more]
