Ontology highlight
ABSTRACT:
SUBMITTER: Aslan K
PROVIDER: S-EPMC7028933 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Aslan Katrin K Turco Verena V Blobner Jens J Sonner Jana K JK Liuzzi Anna Rita AR Núñez Nicolás Gonzalo NG De Feo Donatella D Kickingereder Philipp P Fischer Manuel M Green Ed E Sadik Ahmed A Friedrich Mirco M Sanghvi Khwab K Kilian Michael M Cichon Frederik F Wolf Lara L Jähne Kristine K von Landenberg Anna A Bunse Lukas L Sahm Felix F Schrimpf Daniel D Meyer Jochen J Alexander Allen A Brugnara Gianluca G Röth Ralph R Pfleiderer Kira K Niesler Beate B von Deimling Andreas A Opitz Christiane C Breckwoldt Michael O MO Heiland Sabine S Bendszus Martin M Wick Wolfgang W Becher Burkhard B Platten Michael M
Nature communications 20200218 1
Intrinsic malignant brain tumors, such as glioblastomas are frequently resistant to immune checkpoint blockade (ICB) with few hypermutated glioblastomas showing response. Modeling patient-individual resistance is challenging due to the lack of predictive biomarkers and limited accessibility of tissue for serial biopsies. Here, we investigate resistance mechanisms to anti-PD-1 and anti-CTLA-4 therapy in syngeneic hypermutated experimental gliomas and show a clear dichotomy and acquired immune het ...[more]