Ontology highlight
ABSTRACT:
SUBMITTER: Segovia-Miranda F
PROVIDER: S-EPMC6899159 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Segovia-Miranda Fabián F Morales-Navarrete Hernán H Kücken Michael M Moser Vincent V Seifert Sarah S Repnik Urska U Rost Fabian F Brosch Mario M Hendricks Alexander A Hinz Sebastian S Röcken Christoph C Lütjohann Dieter D Kalaidzidis Yannis Y Schafmayer Clemens C Brusch Lutz L Hampe Jochen J Zerial Marino M
Nature medicine 20191202 12
Early disease diagnosis is key to the effective treatment of diseases. Histopathological analysis of human biopsies is the gold standard to diagnose tissue alterations. However, this approach has low resolution and overlooks 3D (three-dimensional) structural changes resulting from functional alterations. Here, we applied multiphoton imaging, 3D digital reconstructions and computational simulations to generate spatially resolved geometrical and functional models of human liver tissue at different ...[more]