Ontology highlight
ABSTRACT:
SUBMITTER: Larsen EK
PROVIDER: S-EPMC6899184 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Larsen Erik K EK Weber Daniel K DK Wang Songlin S Gopinath Tata T Blackwell Daniel J DJ Dalton Michael P MP Robia Seth L SL Gao Jiali J Veglia Gianluigi G
Biochimica et biophysica acta. Biomembranes 20190807 1
Hematopoietic-substrate-1 associated protein X-1 (HAX-1) is a 279 amino acid protein expressed ubiquitously. In cardiac muscle, HAX-1 was found to modulate the sarcoendoplasmic reticulum calcium ATPase (SERCA) by shifting its apparent Ca<sup>2+</sup> affinity (pCa). It has been hypothesized that HAX-1 binds phospholamban (PLN), enhancing its inhibitory function on SERCA. HAX-1 effects are reversed by cAMP-dependent protein kinase A that phosphorylates PLN at Ser16. To date, the molecular mechani ...[more]