Ontology highlight
ABSTRACT:
SUBMITTER: Ptasinska A
PROVIDER: S-EPMC6899442 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ptasinska Anetta A Pickin Anna A Assi Salam A SA Chin Paulynn Suyin PS Ames Luke L Avellino Roberto R Gröschel Stefan S Delwel Ruud R Cockerill Peter N PN Osborne Cameron S CS Bonifer Constanze C
Cell reports 20190901 12
Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hematopoietic master regulator RUNX1. We previously showed that the maintenance of t(8;21) AML is dependent on RUNX1-ETO expression. Its depletion causes extensive changes in transcription factor binding, as well as gene expression, and initiates myeloid d ...[more]