Dataset Information
Accelerated free-breathing whole-heart 3D T2 mapping with high isotropic resolution.
Ontology highlight
ABSTRACT: Purpose
To enable free-breathing whole-heart 3D T2 mapping with high isotropic resolution in a clinically feasible and predictable scan time. This 3D motion-corrected undersampled signal matched (MUST) T2 map is achieved by combining an undersampled motion-compensated T2 -prepared Cartesian acquisition with a high-order patch-based reconstruction.Methods
The 3D MUST-T2 mapping acquisition consists of an electrocardiogram-triggered, T2 -prepared, balanced SSFP sequence with nonselective saturation pulses. Three undersampled T2 -weighted volumes are acquired using a 3D Cartesian variable-density sampling with increasing T2 preparation times. A 2D image-based navigator is used to correct for respiratory motion of the heart and allow 100% scan efficiency. Multicontrast high-dimensionality undersampled patch-based reconstruction is used in concert with dictionary matching to generate 3D T2 maps. The proposed framework was evaluated in simulations, phantom experiments, and in vivo (10 healthy subjects, 2 patients) with 1.5-mm3 isotropic resolution. Three-dimensional MUST-T2 was compared against standard multi-echo spin-echo sequence (phantom) and conventional breath-held single-shot 2D SSFP T2 mapping (in vivo).Results
Three-dimensional MUST-T2 showed high accuracy in phantom experiments (R2 > 0.99). The precision of T2 values was similar for 3D MUST-T2 and 2D balanced SSFP T2 mapping in vivo (5 ± 1 ms versus 4 ± 2 ms, P = .52). Slightly longer T2 values were observed with 3D MUST-T2 in comparison to 2D balanced SSFP T2 mapping (50.7 ± 2 ms versus 48.2 ± 1 ms, P < .05). Preliminary results in patients demonstrated T2 values in agreement with literature values.Conclusion
The proposed approach enables free-breathing whole-heart 3D T2 mapping with high isotropic resolution in about 8 minutes, achieving accurate and precise T2 quantification of myocardial tissue in a clinically feasible scan time.
SUBMITTER: Bustin A
PROVIDER: S-EPMC6899588 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Accelerated free-breathing whole-heart 3D T<sub>2</sub> mapping with high isotropic resolution.
Magnetic resonance in medicine 20190919 3
<h4>Purpose</h4>To enable free-breathing whole-heart 3D T<sub>2</sub> mapping with high isotropic resolution in a clinically feasible and predictable scan time. This 3D motion-corrected undersampled signal matched (MUST) T<sub>2</sub> map is achieved by combining an undersampled motion-compensated T<sub>2</sub> -prepared Cartesian acquisition with a high-order patch-based reconstruction.<h4>Methods</h4>The 3D MUST-T<sub>2</sub> mapping acquisition consists of an electrocardiogram-triggered, T<su ...[more]