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Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes.

ABSTRACT: A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.

SUBMITTER: Liu ZL

PROVIDER: S-EPMC6899605 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes.

Liu Zheng-Li ZL Yang Chao C Xue Qi-Yan QY Zhao Meng M Shan Cui-Cui CC Xu Yun-He YH Loh Teck-Peng TP

Angewandte Chemie (International ed. in English) 20191004 46

A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol. ...[more]

PMID: 31532868

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