Ontology highlight
ABSTRACT:
SUBMITTER: Bieszczad B
PROVIDER: S-EPMC6900123 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191011 47
We report herein a visible light-mediated C-H hydroxyalkylation of quinolines and isoquinolines that proceeds via a radical path. The process exploits the excited-state reactivity of 4-acyl-1,4-dihydropyridines, which can readily generate acyl radicals upon blue light absorption. By avoiding the need for external oxidants, this radical-generating strategy enables a departure from the classical, oxidative Minisci-type pattern and unlocks a unique reactivity, leading to hydroxyalkylated heteroaren ...[more]