Transceive phase mapping using the PLANET method and its application for conductivity mapping in the brain.

ABSTRACT: PURPOSE:To demonstrate feasibility of transceive phase mapping with the PLANET method and its application for conductivity reconstruction in the brain. METHODS:Accuracy and precision of transceive phase (?± ) estimation with PLANET, an ellipse fitting approach to phase-cycled balanced steady state free precession (bSSFP) data, were assessed with simulations and measurements and compared to standard bSSFP. Measurements were conducted on a homogeneous phantom and in the brain of healthy volunteers at 3 tesla. Conductivity maps were reconstructed with Helmholtz-based electrical properties tomography. In measurements, PLANET was also compared to a reference technique for transceive phase mapping, i.e., spin echo. RESULTS:Accuracy and precision of ?± estimated with PLANET depended on the chosen flip angle and TR. PLANET-based ?± was less sensitive to perturbations induced by off-resonance effects and partial volume (e.g., white matter + myelin) than bSSFP-based ?± . For flip angle = 25° and TR = 4.6 ms, PLANET showed an accuracy comparable to that of reference spin echo but a higher precision than bSSFP and spin echo (factor of 2 and 3, respectively). The acquisition time for PLANET was ~5 min; 2 min faster than spin echo and 8 times slower than bSSFP. However, PLANET simultaneously reconstructed T1 , T2 , B0 maps besides mapping ?± . In the phantom, PLANET-based conductivity matched the true value and had the smallest spread of the three methods. In vivo, PLANET-based conductivity was similar to spin echo-based conductivity. CONCLUSION:Provided that appropriate sequence parameters are used, PLANET delivers accurate and precise ?± maps, which can be used to reconstruct brain tissue conductivity while simultaneously recovering T1 , T2 , and B0 maps.

SUBMITTER: Gavazzi S 

PROVIDER: S-EPMC6900152 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature