Ontology highlight
ABSTRACT:
SUBMITTER: Le P
PROVIDER: S-EPMC6900183 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Le Philipp P Nodwell Matthew B MB Eirich Jürgen J Sieber Stephan A SA
Chemistry (Weinheim an der Bergstrasse, Germany) 20190903 54
The illudin natural product family are fungal secondary metabolites with a characteristic spirocyclopropyl-substituted fused 6,5-bicyclic ring system. They have been extensively studied for their cytotoxicity in various tumor cell types, and semisynthetic derivatives with improved therapeutic characteristics have progressed to clinical trials. Although it is believed that this potent alkylating compound class acts mainly through DNA modification, little is known about its binding to protein site ...[more]