3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T₁ -weighted images.

ABSTRACT:

Background

Previous quantitative synthetic MRI of the brain has been solely performed in 2D.

Purpose

To evaluate the feasibility of the recently developed sequence 3D-QALAS for brain cortical thickness and volumetric analysis.

Study type

Reproducibility/repeatability study.

Subjects

Twenty-one healthy volunteers (35.6 ± 13.8 years).

Field strength/sequence

3D T₁ -weighted fast spoiled gradient recalled echo (FSPGR) sequence was performed once, and 3D-QALAS sequence was performed twice with a 3T scanner.

Assessment

FreeSurfer and FIRST were used to measure cortical thickness and volume of subcortical structures, respectively. Agreement with FSPGR and scan-rescan repeatability were evaluated for 3D-QALAS.

Statistical tests

Percent

SUBMITTER: Fujita S 

PROVIDER: S-EPMC6900192 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature