Dataset Information

3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T₁ -weighted images.

ABSTRACT:

Background

Previous quantitative synthetic MRI of the brain has been solely performed in 2D.

Purpose

To evaluate the feasibility of the recently developed sequence 3D-QALAS for brain cortical thickness and volumetric analysis.

Study type

Reproducibility/repeatability study.

Subjects

Twenty-one healthy volunteers (35.6 ± 13.8 years).

Field strength/sequence

3D T₁ -weighted fast spoiled gradient recalled echo (FSPGR) sequence was performed once, and 3D-QALAS sequence was performed twice with a 3T scanner.

Assessment

FreeSurfer and FIRST were used to measure cortical thickness and volume of subcortical structures, respectively. Agreement with FSPGR and scan-rescan repeatability were evaluated for 3D-QALAS.

Statistical tests

Percent relative difference and intraclass correlation coefficient (ICC) were used to assess reproducibility and scan-rescan repeatability of the 3D-QALAS sequence-derived measurements.

Results

Percent relative difference compared with FSPGR in cortical thickness of the whole cortex was 3.1%, and 89% of the regional areas showed less than 10% relative difference in cortical thickness. The mean ICC across all regions was 0.65, and 74% of the structures showed substantial to almost perfect agreement. For volumes of subcortical structures, the median percent relative differences were lower than 10% across all subcortical structures, except for the accumbens area, and all structures showed ICCs of substantial to almost perfect agreement. For the scan-rescan test, percent relative difference in cortical thickness of the whole cortex was 2.3%, and 97% of the regional areas showed less than 10% relative difference in cortical thickness. The mean ICC across all regions was 0.73, and 80% showed substantial to almost perfect agreement. For volumes of subcortical structures, relative differences were less than 10% across all subcortical structures except for the accumbens area, and all structures showed ICCs of substantial to almost perfect agreement.

Data conclusion

3D-QALAS could be reliably used for measuring cortical thickness and subcortical volumes in most brain regions.

Level of evidence

3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:1834-1842.

SUBMITTER: Fujita S

PROVIDER: S-EPMC6900192 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T<sub>1</sub> -weighted images.

Fujita Shohei S Hagiwara Akifumi A Hori Masaaki M Warntjes Marcel M Kamagata Koji K Fukunaga Issei I Goto Masami M Takuya Haruyama H Takasu Kohei K Andica Christina C Maekawa Tomoko T Takemura Mariko Yoshida MY Irie Ryusuke R Wada Akihiko A Suzuki Michimasa M Aoki Shigeki S

Journal of magnetic resonance imaging : JMRI 20190410 6

<h4>Background</h4>Previous quantitative synthetic MRI of the brain has been solely performed in 2D.<h4>Purpose</h4>To evaluate the feasibility of the recently developed sequence 3D-QALAS for brain cortical thickness and volumetric analysis.<h4>Study type</h4>Reproducibility/repeatability study.<h4>Subjects</h4>Twenty-one healthy volunteers (35.6 ± 13.8 years).<h4>Field strength/sequence</h4>3D T<sub>1</sub> -weighted fast spoiled gradient recalled echo (FSPGR) sequence was performed once, and 3 ...[more]

PMID: 30968991

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Dataset Information

3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T₁ -weighted images.

Background

Purpose

Study type

Subjects

Field strength/sequence

Assessment

Statistical tests

Results

Data conclusion

Level of evidence

Publications

3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T<sub>1</sub> -weighted images.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T1 -weighted images.

Background

Purpose

Study type

Subjects

Field strength/sequence

Assessment

Statistical tests

Results

Data conclusion

Level of evidence

Publications

3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T<sub>1</sub> -weighted images.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T₁ -weighted images.