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Visible Light Induced Metal-Free Carbene N-Carbazolation.

ABSTRACT: Metal-free N-H functionalization reactions represent an important strategy for sustainable C-N coupling reactions. In this report, we describe the visible light photolysis of aryl diazoacetates in the presence of some N-heterocycles that enables mild, metal-free N-H functionalization reactions of carbazole and azepine heterocycles (15 examples, up to 83% yield).

SUBMITTER: Empel C

PROVIDER: S-EPMC6900254 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Visible Light Induced Metal-Free Carbene N-Carbazolation.

Empel Claire C Patureau Frederic W FW Koenigs Rene M RM

The Journal of organic chemistry 20190815 17

Metal-free N-H functionalization reactions represent an important strategy for sustainable C-N coupling reactions. In this report, we describe the visible light photolysis of aryl diazoacetates in the presence of some N-heterocycles that enables mild, metal-free N-H functionalization reactions of carbazole and azepine heterocycles (15 examples, up to 83% yield). ...[more]

PMID: 31373201

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