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High serum concentration of vitamin D may protect against multiple sclerosis.

ABSTRACT: Background:High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals. Objective:Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent. Methods:Prospectively drawn blood samples from individuals later developing relapsing-remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry. Results:High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50-0.93). Conclusion:These findings further support a role for vitamin D in MS aetiology.

SUBMITTER: Bistrom M

PROVIDER: S-EPMC6900627 | biostudies-literature | 2019 Oct-Dec

REPOSITORIES: biostudies-literature

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High serum concentration of vitamin D may protect against multiple sclerosis.

Biström Martin M Alonso-Magdalena Lucia L Andersen Oluf O Jons Daniel D Gunnarsson Martin M Vrethem Magnus M Hultdin Johan J Sundström Peter P

Multiple sclerosis journal - experimental, translational and clinical 20191001 4

<h4>Background</h4>High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals.<h4>Objective</h4>Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent.<h4>Methods</h4>Prospectively drawn blood samples from individuals later developing relapsing-remitting multiple sclerosis and controls matched for biobank, sex, age and date of s ...[more]

PMID: 31839980

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