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A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite.

ABSTRACT: Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of Peroxynitrite (ONOO-). DCM-Bpin exhibits selective fluorescence off-on response for ONOO^- over other reactive oxygen species, including H₂O₂. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO^- in HeLa cells.

SUBMITTER: Wu L

PROVIDER: S-EPMC6900745 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite.

Wu Luling L Tian Xue X Han Hai-Hao HH Wang Jie J Groleau Robin R RR Tosuwan Paramabhorn P Wannalerse Boontana B Sedgwick Adam C AC Bull Steven D SD He Xiao-Peng XP James Tony D TD

ChemistryOpen 20191209 12

Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of Peroxynitrite (ONOO-). DCM-Bpin exhibits selective fluorescence off-on response for ONOO- over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO- in HeLa cells. ...[more]

PMID: 31867147

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