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A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite.


ABSTRACT: Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of Peroxynitrite (ONOO-). DCM-Bpin exhibits selective fluorescence off-on response for ONOO- over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO- in HeLa cells.

SUBMITTER: Wu L 

PROVIDER: S-EPMC6900745 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Herein, we report the evaluation and synthesis of a reaction based fluorescent probe <b>DCM-Bpin</b> for the detection of Peroxynitrite (ONOO-). <b>DCM-Bpin</b> exhibits selective fluorescence off-on response for ONOO<sup>-</sup> over other reactive oxygen species, including H<sub>2</sub>O<sub>2</sub>. Moreover, <b>DCM-Bpin</b> is biocompatible and has been used to visualize exogenous ONOO<sup>-</sup> in HeLa cells. ...[more]

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