Ontology highlight
ABSTRACT:
SUBMITTER: Chun E
PROVIDER: S-EPMC6901086 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Chun Eunyoung E Lavoie Sydney S Fonseca-Pereira Diogo D Bae Sena S Michaud Monia M Hoveyda Hamid R HR Fraser Graeme L GL Gallini Comeau Carey Ann CA Glickman Jonathan N JN Fuller Miles H MH Layden Brian T BT Garrett Wendy S WS
Immunity 20191015 5
Group 3 innate lymphoid cells (ILC3s) sense environmental signals that are critical for gut homeostasis and host defense. However, the metabolite-sensing G-protein-coupled receptors that regulate colonic ILC3s remain poorly understood. We found that colonic ILC3s expressed Ffar2, a microbial metabolite-sensing receptor, and that Ffar2 agonism promoted ILC3 expansion and function. Deficiency of Ffar2 in ILC3s decreased their in situ proliferation and ILC3-derived interleukin-22 (IL-22) production ...[more]