Childhood stress impairs social function through AVP-dependent mechanisms.
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ABSTRACT:
SUBMITTER: Brydges NM
PROVIDER: S-EPMC6901493 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Childhood stress impairs social function through AVP-dependent mechanisms.
Brydges Nichola M NM Hall Jessica J Best Caroline C Rule Lowenna L Watkin Holly H Drake Amanda J AJ Lewis Catrin C Thomas Kerrie L KL Hall Jeremy J
Translational psychiatry 20191209 1
Impaired social function is a core feature of many psychiatric illnesses. Adverse experiences during childhood increase risk for mental illness, however it is currently unclear whether stress early in life plays a direct role in the development of social difficulties. Using a rat model of pre-pubertal stress (PPS), we investigated effects on social behaviour, oxytocin and arginine vasopressin (AVP) in the periphery (plasma) and centrally in the paraventricular and supraoptic hypothalamic nuclei. ...[more]
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