Ontology highlight
ABSTRACT:
SUBMITTER: Ghysels A
PROVIDER: S-EPMC6901538 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ghysels An A Krämer Andreas A Venable Richard M RM Teague Walter E WE Lyman Edward E Gawrisch Klaus K Pastor Richard W RW
Nature communications 20191209 1
The functional significance of ordered nanodomains (or rafts) in cholesterol rich eukaryotic cell membranes has only begun to be explored. This study exploits the correspondence of cellular rafts and liquid ordered (L<sub>o</sub>) phases of three-component lipid bilayers to examine permeability. Molecular dynamics simulations of L<sub>o</sub> phase dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylcholine (DOPC), and cholesterol show that oxygen and water transit a leaflet through the D ...[more]