Ontology highlight
ABSTRACT:
SUBMITTER: Pawar NJ
PROVIDER: S-EPMC6901730 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Pawar Nitin J NJ Wang Lei L Higo Takuya T Bhattacharya Chandrabali C Kancharla Pavan K PK Zhang Fuming F Baryal Kedar K Huo Chang-Xin CX Liu Jian J Linhardt Robert J RJ Huang Xuefei X Hsieh-Wilson Linda C LC
Angewandte Chemie (International ed. in English) 20191106 51
The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical roles in many important biological processes. However, an understanding of their specific functions has been hampered by an inability to synthesize large numbers of diverse, yet defined, HS structures. Herein, we describe a new approach to access the four core disaccharides required for HS/heparin oligosaccharide assembly from natural polysaccharides. The use of disaccharides rather than monosaccharides as ...[more]