Regional hypothermia improves gastric microcirculatory oxygenation during hemorrhage in dogs.

ABSTRACT: Mild systemic hypothermia increases gastric mucosal oxygenation (?HbO2) during hemorrhagic shock in dogs. In the context of critical blood loss hypothermia might be fatal due to adverse side effects. Selective regional hypothermia might overcome these limitations. The aim of our study was to analyze the effects of regional gastric and oral mucosal hypothermia on ?HbO2 and perfusion (?flow). In a cross-over study six anesthetized dogs were subjected to local oral and gastric mucosal hypothermia (34°C), or maintenance of local normothermia during normovolemia and hemorrhage (-20% blood volume). Macro- and microcirculatory variables were recorded continuously. During normovolemia, local hypothermia increased gastric microcirculatory flow (?flow) without affecting oxygenation (?HbO2) or oral microcirculation. During mild hemorrhagic shock gastric ?HbO2 decreased from 72±2% to 38±3% in the normothermic group. This was attenuated by local hypothermia, where ?HbO2 was reduced from 74±3% to 52±4%. Local perfusion, oral microcirculation and macrocirculatory variables were not affected. Selective local hypothermia improves gastric ?HbO2 during hemorrhagic shock without relevant side effects. In contrast to systemic hypothermia, regional mucosal hypothermia did not affect perfusion and oxygen supply during hemorrhage. Thus, the increased ?HbO2 during local hypothermia rather indicates reduced mucosal oxygen demand.

SUBMITTER: Truse R 

PROVIDER: S-EPMC6903746 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature