Unknown

Dataset Information

0

Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Feasibility of a Pilot Randomized Controlled Trial.


ABSTRACT: BACKGROUND:Young-adult heart transplant recipients transferring to adult care are at risk for poor health outcomes. We conducted a pilot randomized controlled trial to determine the feasibility of and to test a transition intervention for young adults who underwent heart transplantation as children and then transferred to adult care. METHODS:Participants were randomized to the transition intervention (4 months long, focused on heart-transplant knowledge, self-care, self-advocacy, and social support) or usual care. Self-report questionnaires and medical records data were collected at baseline and 3 and 6 months after the initial adult clinic visit. Longitudinal analyses comparing outcomes over time were performed using generalized estimating equations and linear mixed models. RESULTS:Transfer to adult care was successful and feasible (ie, excellent participation rates). The average patient standard deviation of mean tacrolimus levels was similar over time in both study arms and < 2.5, indicating adequate adherence. There were no between-group or within-group differences in percentage of tacrolimus bioassays within target range (> 50%). Average overall adherence to treatment was similarly good in both groups. Rates of appointment keeping through 6 months after transfer declined over time in both groups. CONCLUSIONS:The feasibility of the study was demonstrated. Our transition intervention did not improve outcomes.

SUBMITTER: Grady KL 

PROVIDER: S-EPMC6904510 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


<h4>Background</h4>Young-adult heart transplant recipients transferring to adult care are at risk for poor health outcomes. We conducted a pilot randomized controlled trial to determine the feasibility of and to test a transition intervention for young adults who underwent heart transplantation as children and then transferred to adult care.<h4>Methods</h4>Participants were randomized to the transition intervention (4 months long, focused on heart-transplant knowledge, self-care, self-advocacy,  ...[more]

Similar Datasets

| S-EPMC5799004 | biostudies-literature
| S-EPMC6547361 | biostudies-literature
| S-EPMC6492557 | biostudies-literature
| S-EPMC9255463 | biostudies-literature
| S-EPMC4806545 | biostudies-literature
| S-EPMC7880582 | biostudies-literature
| S-EPMC6531445 | biostudies-literature
| S-EPMC9610548 | biostudies-literature
| S-EPMC8188313 | biostudies-literature
| S-EPMC3922232 | biostudies-literature