Ontology highlight
ABSTRACT:
SUBMITTER: Havenar-Daughton C
PROVIDER: S-EPMC6905039 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Cell reports 20191101 7
The first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes (LNs), we tracked the kinetics of the primary immune response in rhesus monkeys immunized intramuscularly (IM) or subcutaneously (s.c.) with an eOD-GT8 60-mer nanoparticle immunogen to facilitate clinical trial design. Significant numbers of germinal center B (B<sub>GC</sub>) cells and antigen-specific CD4 T cells wer ...[more]