Ontology highlight
ABSTRACT:
SUBMITTER: Francis R
PROVIDER: S-EPMC6905862 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Francis Roshane R Guo Haiyang H Streutker Catherine C Ahmed Musaddeque M Yung Theodora T Dirks Peter B PB He Housheng Hansen HH Kim Tae-Hee TH
Science advances 20191211 12
Transcription factors (TFs) are spatially and temporally regulated during gut organ specification. Although accumulating evidence shows aberrant reactivation of developmental programs in cancer, little is known about how TFs drive lineage specification in development and cancer. We first defined gastrointestinal tissue-specific chromatin accessibility and gene expression during development, identifying the dynamic epigenetic regulation of SOX family of TFs. We revealed that <i>Sox2</i> is not on ...[more]