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Noninvasive continuous monitoring of physiological glucose using a monosaccharide-sensing contact lens.

ABSTRACT: We have tested the feasibility of tear glucose sensing using a daily, disposable contact lens embedded with boronic acid-containing fluorophores as a potential alternative to current invasive glucose-monitoring techniques. Our findings show that our approach may, indeed, be suitable for the continuous monitoring of tear glucose levels in the range 50-500 microM, which track blood glucose levels that are approximately 5-10-fold higher. We compare the response of the boronic acid probes in the contact lens to solution-based measurements and can conclude that both the pH and polarity within the contact lens need to be considered with respect to choosing/designing and optimizing glucose-sensing probes for contact lenses.

SUBMITTER: Badugu R

PROVIDER: S-EPMC6906081 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature

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Noninvasive continuous monitoring of physiological glucose using a monosaccharide-sensing contact lens.

Badugu Ramachandram R Lakowicz Joseph R JR Geddes Chris D CD

Analytical chemistry 20040201 3

We have tested the feasibility of tear glucose sensing using a daily, disposable contact lens embedded with boronic acid-containing fluorophores as a potential alternative to current invasive glucose-monitoring techniques. Our findings show that our approach may, indeed, be suitable for the continuous monitoring of tear glucose levels in the range 50-500 microM, which track blood glucose levels that are approximately 5-10-fold higher. We compare the response of the boronic acid probes in the con ...[more]

PMID: 14750854

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