Ontology highlight
ABSTRACT:
SUBMITTER: Mueller-Breckenridge AJ
PROVIDER: S-EPMC6906359 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Mueller-Breckenridge Alan J AJ Garcia-Alcalde Fernando F Wildum Steffen S Smits Saskia L SL de Man Robert A RA van Campenhout Margo J H MJH Brouwer Willem P WP Niu Jianjun J Young John A T JAT Najera Isabel I Zhu Lina L Wu Daitze D Racek Tomas T Hundie Gadissa Bedada GB Lin Yong Y Boucher Charles A CA van de Vijver David D Haagmans Bart L BL
Scientific reports 20191211 1
Chronic infection with Hepatitis B virus (HBV) is a major risk factor for the development of advanced liver disease including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The relative contribution of virological factors to disease progression has not been fully defined and tools aiding the deconvolution of complex patient virus profiles is an unmet clinical need. Variable viral mutant signatures develop within individual patients due to the low-fidelity replication of the viral polym ...[more]