Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC6907693 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Kumar Suresh S Gu Yuexi Y Abudu Yakubu Princely YP Bruun Jack-Ansgar JA Jain Ashish A Farzam Farzin F Mudd Michal M Anonsen Jan Haug JH Rusten Tor Erik TE Kasof Gary G Ktistakis Nicholas N Lidke Keith A KA Johansen Terje T Deretic Vojo V
Developmental cell 20190228 1
Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the ATG13<sup>+</sup>FIP200<sup>+</sup> mammalian pre-autophagosomal structure (mPAS) in response to induction of autophagy. TBK1 phosphorylates Stx17 at S202. During autophagy induction, Stx17<sup>pS202</sup> transfers from the Golgi, where its s ...[more]