Ontology highlight
ABSTRACT:
SUBMITTER: Herhaus L
PROVIDER: S-EPMC6945063 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Herhaus Lina L Bhaskara Ramachandra M RM Lystad Alf Håkon AH Gestal-Mato Uxía U Covarrubias-Pinto Adriana A Bonn Florian F Simonsen Anne A Hummer Gerhard G Dikic Ivan I
EMBO reports 20191111 1
Autophagy is a highly conserved catabolic process through which defective or otherwise harmful cellular components are targeted for degradation via the lysosomal route. Regulatory pathways, involving post-translational modifications such as phosphorylation, play a critical role in controlling this tightly orchestrated process. Here, we demonstrate that TBK1 regulates autophagy by phosphorylating autophagy modifiers LC3C and GABARAP-L2 on surface-exposed serine residues (LC3C S93 and S96; GABARAP ...[more]